• Bioactivity Screening of Microalgae for Antioxidant, Anti-Inflammatory, Anticancer, Anti-Diabetes, and Antibacterial Activities 

      Lauritano, Chiara; Andersen, Jeanette hammer; Hansen, Espen; Albrigtsen, Marte; Escalera, Laura; Esposito, Francesco; Helland, Kirsti; Østnes Hanssen, Kine; Romano, Giovanna; Ianora, Adrianna (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
      Marine microalgae are considered a potentially new and valuable source of biologically active molecules for applications in the food industry as well as in the pharmaceutical, nutraceutical, and cosmetic sectors. They can be easily cultured, have short generation times and enable an environmentally-friendly approach to drug discovery by overcoming problems associated with the over-utilization ...
    • Determination of Lipid Hydroperoxides in Marine Diatoms by the FOX2 Assay 

      Orefice, Ida; Gerecht, Andrea Cornelia; d'Ippolito, G; Fontana, Angelo; Ianora, Adrianna; Romano, Giovanna (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-11)
      Ecologically-relevant marine diatoms produce a plethora of bioactive oxylipins deriving from fatty acid oxidation, including aldehydes, hydroxy-fatty acids, epoxy-hydroxy-fatty acids, and oxo-acids. These secondary metabolites have been related to the negative effect of diatoms on copepod reproduction, causing low hatching success and teratogenesis in the offspring during periods of intense diatom ...
    • Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity 

      Lauritano, Chiara; Helland, Kirsti; Riccio, Gennaro; Andersen, Jeanette Hammer; Ianora, Adrianna; Hansen, Espen Holst (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-17)
      Microalgae have been shown to be excellent producers of lipids, pigments, carbohydrates, and a plethora of secondary metabolites with possible applications in the pharmacological, nutraceutical, and cosmeceutical sectors. Recently, various microalgal raw extracts have been found to have anti-inflammatory properties. In this study, we performed the fractionation of raw extracts of the diatom ...
    • The marine biodiscovery pipeline and ocean medicines of tomorrow 

      Jaspars, Marcel; de Pascale, Donatella; Andersen, Jeannette Hammer; Reyes, Fernando; Crawford, Alex D.; Ianora, Adrianna (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-01)
      Marine organisms possess the capacity to produce a variety of unique and biologically potent natural products for treating human diseases, many of which are currently commercially available or are in advanced clinical trials. Here we provide a short review on progress in the field and discuss a case study of an EU-funded project, PharmaSea, which aims to discover novel products for the treatment of ...
    • Probing the therapeutic potential of marine phyla by spe extraction 

      Moreiras-Figueruelo, Alejandro; Nuzzo, Genoveffa; Galasso, Christian; Sansone, Clementina; Crocetta, Fabio; Mazzella, Valerio; Gallo, Carmela; Barra, Giusi; Sardo, Angela; Iuliano, Antonella; Manzo, Emiliano; D’ippolito, Giuliana; Albrigtsen, Marte; Andersen, Jeanette H.; Ianora, Adrianna; Fontana, Angelo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-16)
      The marine environment is potentially a prolific source of small molecules with significant biological activities. In recent years, the development of new chromatographic phases and the progress in cell and molecular techniques have facilitated the search for marine natural products (MNPs) as novel pharmacophores and enhanced the success rate in the selection of new potential drug candidates. However, ...